Microdissection of Distinct Morphological Regions Within Uveal Melanomas Identifies Novel Drug Targets
Elsa Toumi, Luke B Hesson, Vivian Lin, Dale Wright, Elektra Hajdu, Li-Anne S Lim, Michael Giblin, Fanfan Zhou, Alexandra Hoffmeister, Farida Zabih, Adrian T Fung, R Max Conway, Svetlana Cherepanoff, Eishi Ashihara, Gerardo Ferrara · 2024
Read Microdissection of Distinct Morphological Regions Within Uveal Melanomas Identifies Novel Drug Targets by Elsa Toumi, Luke B Hesson, Vivian Lin, Dale Wright, Elektra Hajdu, Li-Anne S Lim, Michael Giblin, Fanfan Zhou, Alexandra Hoffmeister, Farida Zabih, Adrian T Fung, R Max Conway, Svetlana Cherepanoff, Eishi Ashihara, Gerardo Ferrara (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674814.txt.
Description
Elsa Toumi and co-authors present a 2024 study on uveal melanoma, a rare but often deadly eye cancer. Tumors of this kind can look different from one region to another, with dark and pale patches side by side. The team asked whether those regions also differ at the molecular level, which could point to new drug targets.
They cut out dark and pale regions separately from large, high-risk tumors and sequenced DNA and RNA from each. In four of seven tumors, the regions carried different sets of gene changes. One finding was a skipped segment in a gene that predicts response to an existing drug. Data from a public cancer atlas added more genes not linked to this cancer before.
Catalog record
| CREATOR | Elsa Toumi, Luke B Hesson, Vivian Lin, Dale Wright, Elektra Hajdu, Li-Anne S Lim, Michael Giblin, Fanfan Zhou, Alexandra Hoffmeister, Farida Zabih, Adrian T Fung, R Max Conway, Svetlana Cherepanoff, Eishi Ashihara, Gerardo Ferrara |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |