Antimicrobial Responses to Bacterial Metabolic Activity and Biofilm Formation Studied Using Microbial Fuel Cell-Based Biosensors
Wenguo Wu, Huiya Hong, Jia Lin, Dayun Yang · 2024
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Description
Wenguo Wu and co-authors build a living sensor for anti-biofilm drugs in a 2024 study. Biofilms, sticky bacterial communities, resist treatment, and screening drugs against them is slow with standard staining methods. Their sensor is a microbial fuel cell seeded with Pseudomonas aeruginosa, a bacterium that makes electricity as it lives, so its output voltage reports both its activity and its film growth.
They dosed the sensor with silver nanoparticles, a known antimicrobial. Staining showed only slight film inhibition at twenty micrograms per milliliter, while the sensor's voltage already dropped at five. Higher doses deepened the effect, and the particles also cut free-floating cell activity and the output of a signaling pigment. The device gives a faster, more sensitive screen.
Catalog record
| CREATOR | Wenguo Wu, Huiya Hong, Jia Lin, Dayun Yang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |