The Role of Radiotherapy to the Primary Site in Oropharyngeal Cancer with Limited Metastases—An Analysis of a Hospital-Based Registry
Michael Kharouta, F. Jeffrey Lorenz, Sean Mahase, Hongyun Shi, Neerav Goyal, Min Yao · 2024
Read The Role of Radiotherapy to the Primary Site in Oropharyngeal Cancer with Limited Metastases—An Analysis of a Hospital-Based Registry by Michael Kharouta, F. Jeffrey Lorenz, Sean Mahase, Hongyun Shi, Neerav Goyal, Min Yao (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674761.txt.
Description
Michael Kharouta and co-authors ask whether aiming radiation at the throat tumor helps patients whose throat cancer has spread to just one other site, in a 2024 paper. Guidance for this limited-spread form of oropharyngeal cancer is thin, above all for cancers tied to the HPV virus. The team mined a national hospital registry for patients whose cancer had reached exactly one distant site, most often the lung.
Just over half of the 1,056 patients received radiation to the primary tumor. In both HPV-positive and HPV-negative groups, that radiation came with better survival, as did chemotherapy. Spread to bone or lung, by contrast, marked worse odds. The authors argue that treating the throat tumor itself still matters even after the cancer has traveled. It is a point of practical guidance where trials are scarce.
Catalog record
| CREATOR | Michael Kharouta, F. Jeffrey Lorenz, Sean Mahase, Hongyun Shi, Neerav Goyal, Min Yao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |