The Role of Activated Stromal Cells in Fibrotic Foci Formation and Reversion
Nataliya Andreevna Basalova, Maksim Alexandrovich Vigovskiy, Vladimir Sergeevich Popov, Evgeniya Alexandrovna Lagereva, Olga Alexandrovna Grigorieva, Anastasia Yuryevna Efimenko · 2024
Read The Role of Activated Stromal Cells in Fibrotic Foci Formation and Reversion by Nataliya Andreevna Basalova, Maksim Alexandrovich Vigovskiy, Vladimir Sergeevich Popov, Evgeniya Alexandrovna Lagereva, Olga Alexandrovna Grigorieva, Anastasia Yuryevna Efimenko (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674712.txt.
Description
Nataliya Basalova and co-authors watch scar tissue form and, surprisingly, unwind in injured mouse lungs. A bleomycin injury sparks lung fibrosis, and the scar's core unit is the fibrotic focus. Marked stromal cells appear very early after injury. They feed the pool of contractile scar cells and mingle with a class of immune cells during the first month.
Then comes the twist. As the lung heals, the same marked cells gather into tidy clusters the team calls remodeling foci. Those clusters seem to help reverse the scar rather than build it. The findings recast activated stromal cells as agents of both damage and repair, and as targets for anti scar drugs.
Catalog record
| CREATOR | Nataliya Andreevna Basalova, Maksim Alexandrovich Vigovskiy, Vladimir Sergeevich Popov, Evgeniya Alexandrovna Lagereva, Olga Alexandrovna Grigorieva, Anastasia Yuryevna Efimenko |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |