Vitamin E Mitigates Apoptosis in Ovarian Granulosa Cells by Inhibiting Zearalenone-Induced Activation of the PERK/eIF-2α/ATF4/Chop Signaling Pathway
Qingxiu Liu, Leli Wang, Lei An, Yafei Liu, Honglei Qu, Shimeng Huang, Lihong Zhao, Yulong Yin, Qiugang Ma · 2024
Read Vitamin E Mitigates Apoptosis in Ovarian Granulosa Cells by Inhibiting Zearalenone-Induced Activation of the PERK/eIF-2α/ATF4/Chop Signaling Pathway by Qingxiu Liu, Leli Wang, Lei An, Yafei Liu, Honglei Qu, Shimeng Huang, Lihong Zhao, Yulong Yin, Qiugang Ma (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674711.txt.
Description
Qingxiu Liu and co-authors show in 2024 how a mold toxin kills ovary support cells in pigs and how vitamin E blunts the harm. Gene reads reveal the toxin wakes a stress pathway inside the cell's protein factory. A receptor blocker test pins the entry route to a hormone receptor.
Vitamin E docks tightly at the pathway's start enzyme in models. Fed vitamin E cuts cell death and stress signals in dishes. Mice on the vitamin keep better ovary function under toxin load. The vitamin thus guards fertility tissue against a common feed toxin.
Catalog record
| CREATOR | Qingxiu Liu, Leli Wang, Lei An, Yafei Liu, Honglei Qu, Shimeng Huang, Lihong Zhao, Yulong Yin, Qiugang Ma |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |