Distinct Transcriptomic and Tumor Microenvironment Profiles in Sinonasal Mucosal Melanoma and Aggressive Cutaneous Melanomas
Manuel Molina-García, María Jesús Rojas-Lechuga, Teresa Torres Moral, Jaume Bagué, Judit Mateu, Cristóbal Langdon, Joan Lop, Vinícius Gonçalves de Souza, Llúcia Alós, Mauricio López-Chacón, Sebastian Podlipnik, Cristina Carrera, Josep Malvehy, Isam Alobid, Rui Milton Patricio da Silva-Júnior, Susana · 2024
Read Distinct Transcriptomic and Tumor Microenvironment Profiles in Sinonasal Mucosal Melanoma and Aggressive Cutaneous Melanomas by Manuel Molina-García, María Jesús Rojas-Lechuga, Teresa Torres Moral, Jaume Bagué, Judit Mateu, Cristóbal Langdon, Joan Lop, Vinícius Gonçalves de Souza, Llúcia Alós, Mauricio López-Chacón, Sebastian Podlipnik, Cristina Carrera, Josep Malvehy, Isam Alobid, Rui Milton Patricio da Silva-Júnior, Susana (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674703.txt.
Description
A research team profiles two melanoma types at the molecular level in this 2024 study. One type grows inside the nose and sinuses and is rare, aggressive, and poorly studied, with a much worse outlook than the common skin form.
The team analyzed thirty-seven tumors from a Barcelona hospital, measuring gene activity with over fourteen hundred immune and cancer probes. Clustering split the tumors into two groups, one holding only skin tumors. Gene differences, pathway analysis, and cell mix estimates were paired with survival data. The aim is practical: to explain why the nasal type behaves so badly and to point at treatments that fit its biology.
Catalog record
| CREATOR | Manuel Molina-García, María Jesús Rojas-Lechuga, Teresa Torres Moral, Jaume Bagué, Judit Mateu, Cristóbal Langdon, Joan Lop, Vinícius Gonçalves de Souza, Llúcia Alós, Mauricio López-Chacón, Sebastian Podlipnik, Cristina Carrera, Josep Malvehy, Isam Alobid, Rui Milton Patricio da Silva-Júnior, Susana |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |