Circulating Tumor DNA for Prediction of Complete Pathological Response to Neoadjuvant Radiochemotherapy in Locally Advanced Rectal Cancer (NEORECT Trial)
Tatiana Mögele, Michael Höck, Florian Sommer, Lena Friedrich, Sebastian Sommer, Maximilian Schmutz, Amadeus Altenburger, Helmut Messmann, Matthias Anthuber, Thomas Kröncke, Georg Stüben, Martin Trepel, Bruno Märkl, Sebastian Dintner, Rainer Claus, Therese Becker · 2024
Read Circulating Tumor DNA for Prediction of Complete Pathological Response to Neoadjuvant Radiochemotherapy in Locally Advanced Rectal Cancer (NEORECT Trial) by Tatiana Mögele, Michael Höck, Florian Sommer, Lena Friedrich, Sebastian Sommer, Maximilian Schmutz, Amadeus Altenburger, Helmut Messmann, Matthias Anthuber, Thomas Kröncke, Georg Stüben, Martin Trepel, Bruno Märkl, Sebastian Dintner, Rainer Claus, Therese Becker (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674684.txt.
Description
Tatiana Mogele and colleagues tested circulating tumor DNA to predict response in rectal cancer. Their 2024 paper covers locally advanced disease treated with chemoradiotherapy. Surgery follows that treatment under standard care. About a third of patients reach complete remission from the first phase alone. That raises the question of whether surgery is always needed.
Watch-and-wait strategies can spare some patients an operation. A reliable blood marker for complete response is still missing. Tumor DNA in blood can track response and leftover disease. The trial drew plasma before, during, and after chemoradiotherapy. Forty patients at one center took part in the study. Changes in tumor DNA were matched against final pathology. The goal is safer selection for non-surgical care.
Catalog record
| CREATOR | Tatiana Mögele, Michael Höck, Florian Sommer, Lena Friedrich, Sebastian Sommer, Maximilian Schmutz, Amadeus Altenburger, Helmut Messmann, Matthias Anthuber, Thomas Kröncke, Georg Stüben, Martin Trepel, Bruno Märkl, Sebastian Dintner, Rainer Claus, Therese Becker |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |