A Rare Case of a Malignant Proliferating Trichilemmal Tumor: A Molecular Study Harboring Potential Therapeutic Significance and a Review of Literature
Mokhtar H Abdelhammed, Hanna Siatecka, A Hafeez Diwan, Christie J Finch, Angela D Haskins, David J Hernandez, Ya Xu, Gürkan Kaya · 2024
Read A Rare Case of a Malignant Proliferating Trichilemmal Tumor: A Molecular Study Harboring Potential Therapeutic Significance and a Review of Literature by Mokhtar H Abdelhammed, Hanna Siatecka, A Hafeez Diwan, Christie J Finch, Angela D Haskins, David J Hernandez, Ya Xu, Gürkan Kaya (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674666.txt.
Description
Mokhtar Abdelhammed and colleagues report a rare scalp tumor whose gene profile points to a treatment, in this case study from twenty twenty-four. Their patient, a woman of sixty-four, had a slowly growing lump on the back of her scalp. A first biopsy elsewhere suggested a cancer spread from elsewhere, a worrying label.
Full removal and close study named the true tumor: a malignant proliferating trichilemmal tumor, arising from hair root sheaths and extraordinarily rare. Its layered keratin pattern is the tell. Gene tests found a TP53 mutation and extra copies of ERBB2, the HER2 gene, among other changes. The mutation pattern also argued against ordinary skin cancer, settling the diagnosis. Because HER2-driven cancers answer to HER2-blocking antibodies in other organs, the authors flag the same avenue here, a rare case where molecular study shapes both the name and the plan.
Catalog record
| CREATOR | Mokhtar H Abdelhammed, Hanna Siatecka, A Hafeez Diwan, Christie J Finch, Angela D Haskins, David J Hernandez, Ya Xu, Gürkan Kaya |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |