The Functional Interaction Between Epstein–Barr Virus and MYC in the Pathogenesis of Burkitt Lymphoma
Sandra Solares, Javier León, Lucía García-Gutiérrez, Christoph FA Vogel, Yegor Vassetzky · 2024
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Description
Sandra Solares and co-authors review how a virus and a growth gene conspire in Burkitt lymphoma in a 2024 paper. The Epstein Barr virus was the first virus shown to transform human cells, found in African children's lymphomas in 1964. Burkitt tumors carry a chromosome swap that unleashes the MYC growth gene.
Most endemic cases and many sporadic ones also carry the virus, yet exactly how infection and the gene swap cooperate is still debated. MYC overdrive pushes B cells to multiply through cell cycle pressure. The review walks through virus linked diseases, then weighs proposed mechanisms joining the two hits. The authors frame the open question for researchers hunting prevention or treatment angles.
Catalog record
| CREATOR | Sandra Solares, Javier León, Lucía García-Gutiérrez, Christoph FA Vogel, Yegor Vassetzky |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |