ALDHHigh Breast Cancer Stem Cells Exhibit a Mesenchymal–Senescent Hybrid Phenotype, with Elevated Metabolic and Migratory Activities
Luis Larrea Murillo, Conor J. Sugden, Bela Ozsvari, Zahra Moftakhar, Ghada S. Hassan, Federica Sotgia, Michael P. Lisanti · 2024
Read ALDHHigh Breast Cancer Stem Cells Exhibit a Mesenchymal–Senescent Hybrid Phenotype, with Elevated Metabolic and Migratory Activities by Luis Larrea Murillo, Conor J. Sugden, Bela Ozsvari, Zahra Moftakhar, Ghada S. Hassan, Federica Sotgia, Michael P. Lisanti (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674378.txt.
Description
Luis Larrea Murillo, Conor Sugden, Bela Ozsvari, and four colleagues characterize an odd hybrid state in breast cancer stem cells in this two thousand twenty-four paper. Cancer stem cells are rare but drive progression, spread, and treatment resistance, and high aldehyde dehydrogenase activity marks them. The team isolated human breast cancer cells with high versus low enzyme levels and compared their traits in depth.
The high-ALDH cells looked mesenchymal, with stronger stemness markers and greater migratory potential, consistent with a shift toward a mobile cell type. Unexpectedly, they also carried raised aging markers, a state usually opposed to aggressive growth. In metabolism they were revved up, with more mitochondrial DNA and mass and higher mitochondrial and glycolytic activity. The authors describe a mesenchymal-senescent hybrid state that may help explain how this subgroup survives therapy and seeds recurrence, marking it as a target for stem-cell-directed treatments.
Catalog record
| CREATOR | Luis Larrea Murillo, Conor J. Sugden, Bela Ozsvari, Zahra Moftakhar, Ghada S. Hassan, Federica Sotgia, Michael P. Lisanti |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |