Current Insights into the Radiobiology of Boron Neutron Capture Therapy and the Potential for Further Improving Biological Effectiveness
Leah D. Punshon, Maria Rita Fabbrizi, Ben Phoenix, Stuart Green, Jason L. Parsons · 2024
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Description
Leah Punshon and four co-authors review a targeted form of radiation therapy in a 2024 article. Standard X-ray treatment often harms healthy tissue near a tumor. The method under review, boron neutron capture therapy, loads cancer cells with boron and then fires neutrons at them, so the killing burst happens inside the cancer cells and spares their neighbors.
The review gathers what lab and animal studies show about how this treatment damages DNA and how cells respond. The main boron carrier in use hitches a ride on a transporter that many cancers overproduce. Newer boron compounds aim to reach tumors more exactly. The authors also note plain limits: few sites can supply the neutrons, and much about the cell response is still unknown. Better carriers and deeper biology, they argue, are the path to wider use.
Catalog record
| CREATOR | Leah D. Punshon, Maria Rita Fabbrizi, Ben Phoenix, Stuart Green, Jason L. Parsons |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |