Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer’s disease
Jiaxin Cindy Tu, Peter R. Millar, Jeremy F. Strain, Andrew Eck, Babatunde Adeyemo, Abraham Z. Snyder, Alisha Daniels, Celeste Karch, Edward D. Huey, Eric McDade, Gregory S. Day, Igor Yakushev, Jason Hassenstab, John Morris, Jorge J. Llibre-Guerra, Laura Ibanez, Mathias Jucker, Patricio Chrem Mendez, · 2024
Read Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer’s disease by Jiaxin Cindy Tu, Peter R. Millar, Jeremy F. Strain, Andrew Eck, Babatunde Adeyemo, Abraham Z. Snyder, Alisha Daniels, Celeste Karch, Edward D. Huey, Eric McDade, Gregory S. Day, Igor Yakushev, Jason Hassenstab, John Morris, Jorge J. Llibre-Guerra, Laura Ibanez, Mathias Jucker, Patricio Chrem Mendez, (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674321.txt.
Description
Jiaxin Cindy Tu and co-authors published this brain network study in 2024. It examines families carrying genes that guarantee Alzheimer's disease. Brain hub regions, the highly connected nodes that keep information flowing, seem especially fragile in such diseases. One theory blames their own heavy activity for wearing them down. The team refined a hub disruption index to test how connectivity breaks down in these mutation carriers.
The breakdown pattern matched a targeted attack on hubs rather than random damage. Strikingly, it was already visible about twelve years before expected symptoms. It grew steadily worse as dementia advanced. The disruption tracked regional connection strength and followed the spread of amyloid plaques seen on brain scans. That order fits the activity-wear theory. The authors say mapping hub damage could sharpen diagnosis. It might also guide treatments aimed at the most burdened brain regions.
Catalog record
| CREATOR | Jiaxin Cindy Tu, Peter R. Millar, Jeremy F. Strain, Andrew Eck, Babatunde Adeyemo, Abraham Z. Snyder, Alisha Daniels, Celeste Karch, Edward D. Huey, Eric McDade, Gregory S. Day, Igor Yakushev, Jason Hassenstab, John Morris, Jorge J. Llibre-Guerra, Laura Ibanez, Mathias Jucker, Patricio Chrem Mendez, |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |