Mitophagy in Doxorubicin-Induced Cardiotoxicity: Insights into Molecular Biology and Novel Therapeutic Strategies
Heng Zhang, Saiyang Xie, Wei Deng, Stanislovas Jankauskas, Lucia Tabares · 2024
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Description
A strong cancer drug saves lives but can scar the heart, and part of that harm runs through the cell's power plants, which a cleanup process normally keeps in good repair. Heng Zhang and co-authors review that cleanup link in a 2024 paper. The cleanup, called mitophagy, wraps worn power plants and digests them before they leak harm.
When the drug jams this cleanup, damaged units pile up and the heart muscle weakens toward failure. Lab work shows that guarding or restoring the cleanup can blunt the drug's heart harm. The catch is translation: the exact steps are still debated, and drugs that push the cleanup may carry side effects of their own. The review maps both the promise and the open questions for safer cancer care.
Catalog record
| CREATOR | Heng Zhang, Saiyang Xie, Wei Deng, Stanislovas Jankauskas, Lucia Tabares |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |