Differential Regulation of Hyaluronan Synthesis by Three Isoforms of Hyaluronan Synthases in Mammalian Cells
Jie Wang, Zhikun Wu, Longtao Cao, Feng Long, Davide Vigetti, Benoit Coulombe · 2024
Read Differential Regulation of Hyaluronan Synthesis by Three Isoforms of Hyaluronan Synthases in Mammalian Cells by Jie Wang, Zhikun Wu, Longtao Cao, Feng Long, Davide Vigetti, Benoit Coulombe (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673962.txt.
Description
Jie Wang and co-authors compare the three enzymes that build hyaluronan in a 2024 cell biology study. Hyaluronan is a key part of the material between cells, and its synthases, HAS1, HAS2, and HAS3, are normally produced at such low levels that studying them has been hard.
The team produced all three human enzymes with protein tags in cultured cells and purified them in workable amounts for the first time. The isoforms turned out to make chains of different lengths and to differ in catalytic efficiency and substrate handling. Tagged versions in living cells let the authors measure how much hyaluronan each one secretes.
Catalog record
| CREATOR | Jie Wang, Zhikun Wu, Longtao Cao, Feng Long, Davide Vigetti, Benoit Coulombe |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |