Steroids and Malignancy Increase Local Heparanase and Decrease Markers of Osteoblast Activity in Bone Tissue Microcirculation
Keren Asayag, Eli Peled, Mai Assalia, Yonatan Crispel, Chen Yanovich, Haim Cohen, Anat Keren-Politansky, Yona Nadir, Masaru Yamaguchi, Peixin Dong · 2024
Read Steroids and Malignancy Increase Local Heparanase and Decrease Markers of Osteoblast Activity in Bone Tissue Microcirculation by Keren Asayag, Eli Peled, Mai Assalia, Yonatan Crispel, Chen Yanovich, Haim Cohen, Anat Keren-Politansky, Yona Nadir, Masaru Yamaguchi, Peixin Dong (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673960.txt.
Description
Keren Asayag and nine co-authors show how steroids and cancer stir clotting inside bone while quieting bone building, in a 2024 study. Both are known to thin bone and raise fracture risk. A protein called heparanase, which boosts clotting and vessel growth, sits at the center.
In lab cells, steroid and cancer media raised heparanase and cut a bone building marker. Blocking pieces of the pathway reversed the effect. Mice on steroids showed the same pattern in their bones. Human biopsies from cancer and steroid damaged bone showed swollen vessels and high clotting markers. The authors suggest heparanase blockers deserve study for preventing fractures and bone pain.
Catalog record
| CREATOR | Keren Asayag, Eli Peled, Mai Assalia, Yonatan Crispel, Chen Yanovich, Haim Cohen, Anat Keren-Politansky, Yona Nadir, Masaru Yamaguchi, Peixin Dong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |