Adenoviral Vectors for Gene Therapy of Hereditary Diseases
Anna Muravyeva, Svetlana Smirnikhina · 2024
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Description
Muravyeva and Smirnikhina review adenoviral vectors for gene therapy of inherited diseases in a 2024 paper. These engineered viruses carry genes efficiently into many cell types. They shine as cancer killers and vaccine platforms, yet hereditary disease trials have disappointed.
The review walks through vector features and the monogenic disease trials run so far. It analyzes why those studies failed to win a lasting place. Immune reactions against the vector are a central obstacle. Current work modifies the viruses to dodge immunity and target tissues precisely. The authors weigh whether such fixes can reopen the field. Hereditary diseases remain the unmet promise. Trial history offers the lessons.
Catalog record
| CREATOR | Anna Muravyeva, Svetlana Smirnikhina |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |