Comparative Effects of GLP-1 and GLP-2 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation
Asif Ali, Dawood Khan, Vaibhav Dubey, Andrei I. Tarasov, Peter R. Flatt, Nigel Irwin · 2024
Read Comparative Effects of GLP-1 and GLP-2 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation by Asif Ali, Dawood Khan, Vaibhav Dubey, Andrei I. Tarasov, Peter R. Flatt, Nigel Irwin (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673903.txt.
Description
Asif Ali and co-authors compare two gut hormones head to head in a 2024 study. GLP-1 is famous for metabolic effects; its sibling GLP-2, from the same precursor, got less attention. Both were tested on insulin release in a beta cell line and in isolated mouse islets across a wide dose range. Real time signals inside the cells were watched as well.
The comparison extends to glucose tolerance and appetite in the whole animal. Knowing where the siblings agree and split guides drug design, since GLP-1 based drugs already fill pharmacies. A peptide that helps the gut without touching appetite, or the reverse, would be a new lever. The study draws the map.
Catalog record
| CREATOR | Asif Ali, Dawood Khan, Vaibhav Dubey, Andrei I. Tarasov, Peter R. Flatt, Nigel Irwin |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |