Apocynin and Hyperbaric Oxygen Therapy Improve Renal Function and Structure in an Animal Model of CKD
Andrija Vukovic, Danijela Karanovic, Nevena D Mihailovic-Stanojevic, Zoran Miloradovic, Predrag Brkic, Maja Zivotic, Jelena Nesovic Ostojic, Milan Ivanov, Sanjin Kovacevic, Una-Jovana Vajic, Djurdjica Jovovic, Silvio R. De Luka · 2024
Read Apocynin and Hyperbaric Oxygen Therapy Improve Renal Function and Structure in an Animal Model of CKD by Andrija Vukovic, Danijela Karanovic, Nevena D Mihailovic-Stanojevic, Zoran Miloradovic, Predrag Brkic, Maja Zivotic, Jelena Nesovic Ostojic, Milan Ivanov, Sanjin Kovacevic, Una-Jovana Vajic, Djurdjica Jovovic, Silvio R. De Luka (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673868.txt.
Description
Andrija Vukovic and a large team of co-authors published a rat study in 2024 on two treatments for chronic kidney disease, a plant compound and oxygen under pressure. The disease scars kidneys progressively, and oxidative damage is a suspect driver. The team induced it by removing five-sixths of the kidney mass, then treated groups with apocynin, hyperbaric oxygen, both, or neither for four weeks.
Every treatment lowered blood pressure against the untreated disease group. Apocynin, alone or combined, also cut protein leaking into urine, a damage marker. All treatments visibly reduced kidney lesions under the microscope, and single treatments lowered desmin, a sign of injured filtering cells. Two different levers, antioxidant and oxygen, each eased the disease's grip in this model.
Catalog record
| CREATOR | Andrija Vukovic, Danijela Karanovic, Nevena D Mihailovic-Stanojevic, Zoran Miloradovic, Predrag Brkic, Maja Zivotic, Jelena Nesovic Ostojic, Milan Ivanov, Sanjin Kovacevic, Una-Jovana Vajic, Djurdjica Jovovic, Silvio R. De Luka |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |