Bacillus amyloliquefaciens Regulates the Keap1/Nrf2 Signaling Pathway to Improve the Intestinal (Caco-2 Cells and Chicken Jejunum) Oxidative Stress Response Induced by Lipopolysaccharide (LPS)
Xing Chen, Aijuan Zheng, Shuzhen Li, Zedong Wang, Zhimin Chen, Jiang Chen, Zhiheng Zou, Haijun Liang, Guohua Liu, Evangelos Zoidis · 2024
Read Bacillus amyloliquefaciens Regulates the Keap1/Nrf2 Signaling Pathway to Improve the Intestinal (Caco-2 Cells and Chicken Jejunum) Oxidative Stress Response Induced by Lipopolysaccharide (LPS) by Xing Chen, Aijuan Zheng, Shuzhen Li, Zedong Wang, Zhimin Chen, Jiang Chen, Zhiheng Zou, Haijun Liang, Guohua Liu, Evangelos Zoidis (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673850.txt.
Description
Xing Chen and co-authors test whether a friendly bacterium can shield the gut from oxidative stress, in a 2024 study. They challenged human gut cells in dishes and broiler chickens with a bacterial toxin that sparks inflammation and cell damage. Groups got the toxin alone, the helpful Bacillus strain alone, both, or neither. Measures covered antioxidant strength, damage markers, and the genes of a master defense pathway.
The bacterium raised antioxidant enzymes and total defense capacity in the cells while cutting a key damage marker. It switched on protective genes, including ones that seal the gut wall and calm inflammation. Similar protection appeared in the chicken gut tissue. The authors trace the effect to the Keap1 and Nrf2 pathway, the cell's main switch for antioxidant defense. They propose the strain as a feed or food aid for gut health.
Catalog record
| CREATOR | Xing Chen, Aijuan Zheng, Shuzhen Li, Zedong Wang, Zhimin Chen, Jiang Chen, Zhiheng Zou, Haijun Liang, Guohua Liu, Evangelos Zoidis |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |