Fucoidan Attenuates Cardiac Remodeling by Inhibiting Galectin-3 Secretion, Fibrosis, and Inflammation in a Mouse Model of Pressure Overload
Wen-Rui Hao, Chun-Han Cheng, Huan-Yuan Chen, Tzu-Hurng Cheng, Ju-Chi Liu, Jin-Jer Chen · 2024
Read Fucoidan Attenuates Cardiac Remodeling by Inhibiting Galectin-3 Secretion, Fibrosis, and Inflammation in a Mouse Model of Pressure Overload by Wen-Rui Hao, Chun-Han Cheng, Huan-Yuan Chen, Tzu-Hurng Cheng, Ju-Chi Liu, Jin-Jer Chen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673818.txt.
Description
Wen-Rui Hao and co-authors test a seaweed extract in mice with an overworked heart in a 2024 study. The extract, fucoidan, comes from marine algae and is known for calming oxidation and immune effects. A protein called galectin-3 drives heart scarring and is a drug target in heart remodeling. The team used surgery to narrow the aorta, forcing the heart to pump against high load.
Treated mice got one of two daily doses. Pressure load raised galectin-3 in the blood, collagen build up, and signs of scarring and swelling. The extract held those changes down, with less collagen and fewer swelling cells entering the heart. The authors see promise for slowing harmful remodeling.
Catalog record
| CREATOR | Wen-Rui Hao, Chun-Han Cheng, Huan-Yuan Chen, Tzu-Hurng Cheng, Ju-Chi Liu, Jin-Jer Chen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |