Mechanical Stretch Control of Adipocyte AKT Signaling and the Role of FAK and ROCK Mechanosensors
Tasneem Bouzid, Eunju Kim, Brandon D Riehl, Ruiguo Yang, Viswanathan Saraswathi, Jason K Kim, Jung Yul Lim, Chun-Yuh Huang, Zhipeng Meng · 2024
Read Mechanical Stretch Control of Adipocyte AKT Signaling and the Role of FAK and ROCK Mechanosensors by Tasneem Bouzid, Eunju Kim, Brandon D Riehl, Ruiguo Yang, Viswanathan Saraswathi, Jason K Kim, Jung Yul Lim, Chun-Yuh Huang, Zhipeng Meng (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673816.txt.
Description
Tasneem Bouzid and colleagues examined how stretching fat cells changes insulin signalling in 2024. Fat tissue in the body is constantly loaded by weight, posture, and movement. Whether fat cells sense that load and adjust metabolic behaviour could matter for obesity and type two diabetes, so the team applied controlled stretch in the laboratory.
Stretch resembling normal body conditions switched on insulin signalling in fat cells. Two force-sensing proteins helped carry that effect, linking physical pull to chemical response. The authors describe the work as the first of its kind and suggest that cyclic stretch of fat tissue, or drugs aimed at those sensors, might one day improve insulin sensitivity.
Catalog record
| CREATOR | Tasneem Bouzid, Eunju Kim, Brandon D Riehl, Ruiguo Yang, Viswanathan Saraswathi, Jason K Kim, Jung Yul Lim, Chun-Yuh Huang, Zhipeng Meng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |