Methods for Rapid Characterization of Tunable Microbubble Formulations
Savannah L Harpster, Alexandra M Piñeiro, Joyce Y Wong, Fabiano Bini, Weijia Wen · 2024
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Description
Savannah Harpster and co-authors set out in twenty twenty-four to speed up the testing of tiny gas bubbles made for medical use. To tune a bubble mix, its size spread, count, and sound response must be gauged fast, so that new mixes can be tried in quick rounds. The team built a joint method that pairs light-based and sound-based tests.
An open-source image tool was adapted to count and size bubbles in bright-field photos. A gel block with many wells was made to catch sound echoes from many bubble samples at once, giving a gauge of how strongly each mix reflects sound. Size, count, and echo strength together show what to change in the next mix. The method gives labs a fast way to compare bubble mixes with varied shell make-ups and to home in on ones fit for use in care.
Catalog record
| CREATOR | Savannah L Harpster, Alexandra M Piñeiro, Joyce Y Wong, Fabiano Bini, Weijia Wen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |