Amino Acid Metabolism and Autophagy in Atherosclerotic Cardiovascular Disease
Yuting Wu, Irem Avcilar-Kücükgöze, Donato Santovito, Dorothee Atzler · 2024
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Description
Wu, Avcilar-Kücükgöze, Santovito, and Atzler published in twenty twenty-four a review of amino acids, cell recycling, and artery disease. Heart and vessel disease kills about one in three people worldwide. Its root is atherosclerosis, a slow inflammatory build-up in artery walls. Immune cells drive much of that process, and their fuel use steers their behavior. Autophagy is the cell's recycling system for worn parts, and amino acids strongly control it.
The review focuses on three amino acids: leucine, arginine, and glutamine. Each one feeds into signals that switch recycling on or off. That switching changes how plaque grows and whether it stays stable. The authors map where these pathways cross. They also point out treatment ideas that might exploit the links.
Catalog record
| CREATOR | Yuting Wu, Irem Avcilar-Kücükgöze, Donato Santovito, Dorothee Atzler |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |