Chitosan Nanoparticle-Mediated Delivery of Alstonia venenata R.Br. Root Methanolic Extract: A Promising Strategy for Breast Cancer Therapy in DMBA-Induced Breast Cancer in Sprague Dawley Rats
Aarthi Jeganathan, Karuppusamy Arunachalam, Anju Byju, Anju Rani George, Sradha Sajeev, Kavimani Thangasamy, Geetha Natesan, Rita Cortesi, Maddalena Sguizzato · 2024
Read Chitosan Nanoparticle-Mediated Delivery of Alstonia venenata R.Br. Root Methanolic Extract: A Promising Strategy for Breast Cancer Therapy in DMBA-Induced Breast Cancer in Sprague Dawley Rats by Aarthi Jeganathan, Karuppusamy Arunachalam, Anju Byju, Anju Rani George, Sradha Sajeev, Kavimani Thangasamy, Geetha Natesan, Rita Cortesi, Maddalena Sguizzato (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673636.txt.
Description
Aarthi Jeganathan and eight co-authors test a plant extract delivered in chitosan nanoparticles against breast cancer in rats, in a two thousand twenty-four drug-science paper. The extract comes from the roots of Alstonia venenata, a Western Ghats plant rich in alkaloids.
Tumors were induced with the chemical DMBA in female Sprague Dawley rats. Nanoparticle-loaded extract greatly reduced tumor volume, burden, and incidence, letting its compounds out slowly. Treated animals showed improved blood and tissue readings, and antioxidant defenses rose while lipid peroxidation fell sharply. The nanoparticle form beat the plain extract at slowing tumor progression. The authors call for work to single out the active compounds and their mechanisms.
Catalog record
| CREATOR | Aarthi Jeganathan, Karuppusamy Arunachalam, Anju Byju, Anju Rani George, Sradha Sajeev, Kavimani Thangasamy, Geetha Natesan, Rita Cortesi, Maddalena Sguizzato |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 96 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |