Erinacine A-Enriched Hericium erinaceus Mycelium Ethanol Extract Lessens Cellular Damage in Cell and Drosophila Models of Spinocerebellar Ataxia Type 3 by Improvement of Nrf2 Activation
Yu-Ling Wu, Hai-Lun Sun, Jui-Chih Chang, Wei-Yong Lin, Pei-Yin Chen, Chin-Chu Chen, Li-Ya Lee, Chien-Chun Li, Mingli Hsieh, Haw-Wen Chen, Ya-Chen Yang, Chin-San Liu, Kai-Li Liu · 2024
Read Erinacine A-Enriched Hericium erinaceus Mycelium Ethanol Extract Lessens Cellular Damage in Cell and Drosophila Models of Spinocerebellar Ataxia Type 3 by Improvement of Nrf2 Activation by Yu-Ling Wu, Hai-Lun Sun, Jui-Chih Chang, Wei-Yong Lin, Pei-Yin Chen, Chin-Chu Chen, Li-Ya Lee, Chien-Chun Li, Mingli Hsieh, Haw-Wen Chen, Ya-Chen Yang, Chin-San Liu, Kai-Li Liu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673478.txt.
Description
Yu-Ling Wu and twelve co-authors published a neuroprotection study in twenty twenty-four on a mushroom extract against spinocerebellar ataxia type 3. The inherited disease comes from a stretched repeat in the ataxin-3 protein, which clumps in neurons and weakens antioxidant defenses. The extract, from lion's mane mycelium, is rich in a compound called erinacine A.
In transgenic fruit flies carrying the human disease gene, the extract extended lifespan and restored movement. In cell models it boosted antioxidant power and cellular cleanup, lowering the mutant protein and its aggregates. The mechanism ran through Nrf2, the master switch for detoxification genes. The authors propose the extract as a candidate therapy worth clinical exploration.
Catalog record
| CREATOR | Yu-Ling Wu, Hai-Lun Sun, Jui-Chih Chang, Wei-Yong Lin, Pei-Yin Chen, Chin-Chu Chen, Li-Ya Lee, Chien-Chun Li, Mingli Hsieh, Haw-Wen Chen, Ya-Chen Yang, Chin-San Liu, Kai-Li Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |