Molecular Docking of Key Compounds from Acacia Honey and Nigella sativa Oil and Experimental Validation for Colitis Treatment in Albino Mice
Mehwish Bibi, Irfan Baboo, Hamid Majeed, Santosh Kumar, Maximilian Lackner, Davide Tagliazucchi · 2024
Read Molecular Docking of Key Compounds from Acacia Honey and Nigella sativa Oil and Experimental Validation for Colitis Treatment in Albino Mice by Mehwish Bibi, Irfan Baboo, Hamid Majeed, Santosh Kumar, Maximilian Lackner, Davide Tagliazucchi (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673436.txt.
Description
Mehwish Bibi and five co-authors tested acacia honey and Nigella sativa oil in two thousand twenty-four against colitis, inflammation of the colon. Current colitis drugs carry limits and side effects, so natural options draw interest. They first modelled on a computer how key compounds in the honey and oil bind proteins tied to inflammation and oxidative stress.
Fructose and glucose showed promising binding to several target proteins. Then, in albino mice with induced colitis, the two substances, alone and combined, cut inflammation and eased symptoms. Tissue checks showed less mucosal damage and fewer immune cells, and blood chemistry improved as well.
Catalog record
| CREATOR | Mehwish Bibi, Irfan Baboo, Hamid Majeed, Santosh Kumar, Maximilian Lackner, Davide Tagliazucchi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |