Mutations in the PIK3C2B, ERBB3, KIT, and MLH1 Genes and Their Relationship with Resistance to Temozolomide in Patients with High-Grade Gliomas
León Darío Ortiz Gómez, Heidy Johanna Contreras Martínez, David Andrés Galvis Pareja, Sara Vélez Gómez, Jorge Emilio Salazar Flórez, Fernando P. Monroy, Ronald Guillermo Peláez Sánchez · 2024
Read Mutations in the PIK3C2B, ERBB3, KIT, and MLH1 Genes and Their Relationship with Resistance to Temozolomide in Patients with High-Grade Gliomas by León Darío Ortiz Gómez, Heidy Johanna Contreras Martínez, David Andrés Galvis Pareja, Sara Vélez Gómez, Jorge Emilio Salazar Flórez, Fernando P. Monroy, Ronald Guillermo Peláez Sánchez (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673431.txt.
Description
León Darío Ortiz Gómez and six co-authors hunt genes beyond the usual suspect that explain why some brain tumors shrug off the standard drug. Their 2024 study follows 31 patients with high-grade gliomas treated with surgery, radiation, and temozolomide. The known resistance route runs through the MGMT enzyme, but patients with the same marker still split in response.
Sequencing 324 cancer genes across the group, the team tied mutations in four genes to the second relapse under treatment: PIK3C2B, KIT, ERBB3, and MLH1. The statistical screen weighed those mutations against the standard regimen and a metronomic dosing variant. The authors propose the four mutations, read alongside MGMT promoter status, as a fuller resistance signature. Bigger cohorts must confirm the panel before clinics can lean on it.
Catalog record
| CREATOR | León Darío Ortiz Gómez, Heidy Johanna Contreras Martínez, David Andrés Galvis Pareja, Sara Vélez Gómez, Jorge Emilio Salazar Flórez, Fernando P. Monroy, Ronald Guillermo Peláez Sánchez |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |