The Potential Causal Association of Apolipoprotein A and B and Age-Related Macular Degeneration: A Mendelian Randomisation Study
Young Lee, Je Hyun Seo, Victor Chong · 2024
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Description
Blood fats may do more than clog arteries; they may also feed the eye disease that steals central vision in old age. Young Lee and Je Hyun Seo test that idea with Mendelian randomisation, a method that uses gene variants as stand-ins for lifelong exposure. Their 2024 study pairs UK Biobank data on two fat-carrying proteins, ApoA and ApoB, with Finnish data on age-related macular degeneration.
ApoA showed a causal link with the disease overall and with both its dry and wet forms in the first pass. Once body weight, inflammation, and smoking entered the model, that link faded. ApoB told the steadier story: higher ApoB went with lower risk of dry disease. The authors say the fat story in this eye disease is real but tangled, and they call for more work before either protein becomes a target.
Catalog record
| CREATOR | Young Lee, Je Hyun Seo, Victor Chong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |