Efficacy and Safety of Pazopanib in the Treatment of Thyroid Cancer: A Systematic Review
Alexandra Laura Mederle, Loredana Gabriela Stana, Adrian Cosmin Ilie, Claudia Borza, Caius Glad Streian, Daciana Nistor, Teodor Cerbulescu, Biliana Belovan, Ana Lascu, Silvia Di Agostino · 2024
Read Efficacy and Safety of Pazopanib in the Treatment of Thyroid Cancer: A Systematic Review by Alexandra Laura Mederle, Loredana Gabriela Stana, Adrian Cosmin Ilie, Claudia Borza, Caius Glad Streian, Daciana Nistor, Teodor Cerbulescu, Biliana Belovan, Ana Lascu, Silvia Di Agostino (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673424.txt.
Description
Alexandra Mederle and co-authors reviewed trials of the cancer drug pazopanib across thyroid cancer types, in a paper published in 2024. The drug blocks several growth signals at once and had been tried in differentiated, medullary, and anaplastic forms of the disease. Following standard review methods, the team gathered six studies covering 289 patients. They compared survival without growth, overall survival, tumor shrinkage, and side effects.
Time without progression ranged from about two to twelve months across studies, and survival from under six months to not yet reached. Between five and forty-nine percent of tumors shrank partly. High blood pressure hit up to seventy-two percent of patients, with fatigue and diarrhea also common, and severe side effects stopped treatment in up to fourteen percent. The authors find real benefit in medullary and stubborn differentiated cancers, little in the anaplastic type, and a side-effect load that needs careful handling.
Catalog record
| CREATOR | Alexandra Laura Mederle, Loredana Gabriela Stana, Adrian Cosmin Ilie, Claudia Borza, Caius Glad Streian, Daciana Nistor, Teodor Cerbulescu, Biliana Belovan, Ana Lascu, Silvia Di Agostino |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |