Oral Squamous Cell Carcinoma and What We Lose During Formalin Fixation: An Evaluation of Changes in Macroscopic Resection Margins Utilizing Virtual Three-Dimensional Imaging Techniques with Analysis Based on 947 Measurements
Adam Michcik, Maksym Jopek, Rafał Pęksa, Piotr Choma, Łukasz Garbacewicz, Adam Polcyn, Barbara Wojciechowska, Tomasz Wach, Maciej Sikora, Paolo Iacoviello, Giovanni Audino, Barbara Drogoszewska, Arkadiusz Dziedzic, Robert Kubina · 2024
Read Oral Squamous Cell Carcinoma and What We Lose During Formalin Fixation: An Evaluation of Changes in Macroscopic Resection Margins Utilizing Virtual Three-Dimensional Imaging Techniques with Analysis Based on 947 Measurements by Adam Michcik, Maksym Jopek, Rafał Pęksa, Piotr Choma, Łukasz Garbacewicz, Adam Polcyn, Barbara Wojciechowska, Tomasz Wach, Maciej Sikora, Paolo Iacoviello, Giovanni Audino, Barbara Drogoszewska, Arkadiusz Dziedzic, Robert Kubina (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673419.txt.
Description
Michcik and co-authors measure how much surgical margins shrink when mouth cancer specimens sit in formalin, in this 2024 study. Surgeons need a clear rim of healthy tissue around a tumor, and shrinkage after removal can mislead that judgment. The team used three-dimensional scans to track the change precisely.
Forty-two patients with tumors of the mouth floor, tongue, or upper jaw took part, with nearly a thousand measurements in all. Tongue specimens shrank the most, up to 28 percent. Many margins that looked safely wide at surgery fell to the borderline range after fixation. The tumors themselves barely changed size. The authors warn that fixation losses should inform how margins are judged.
Catalog record
| CREATOR | Adam Michcik, Maksym Jopek, Rafał Pęksa, Piotr Choma, Łukasz Garbacewicz, Adam Polcyn, Barbara Wojciechowska, Tomasz Wach, Maciej Sikora, Paolo Iacoviello, Giovanni Audino, Barbara Drogoszewska, Arkadiusz Dziedzic, Robert Kubina |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |