Beneficial Actions of 4-Methylumbelliferone in Type 1 Diabetes by Promoting β Cell Renewal and Inhibiting Dedifferentiation
Wencheng Zhang, Shuo Yang, Xinwen Yu, Shanshan Zhu, Xin Wang, Fei Sun, Shengru Liang, Xiaoguang Wang, Guohong Zhao, Bin Gao, Marie Černá, Bo-Ying Bao · 2024
Read Beneficial Actions of 4-Methylumbelliferone in Type 1 Diabetes by Promoting β Cell Renewal and Inhibiting Dedifferentiation by Wencheng Zhang, Shuo Yang, Xinwen Yu, Shanshan Zhu, Xin Wang, Fei Sun, Shengru Liang, Xiaoguang Wang, Guohong Zhao, Bin Gao, Marie Černá, Bo-Ying Bao (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673412.txt.
Description
Wencheng Zhang and co-authors test a plant derived drug in type one diabetes mice in a 2024 paper. The disease kills insulin making beta cells in the pancreas. Treated mice got the drug for three weeks after disease induction. Blood sugar, insulin, and islet tissue were tracked across groups.
Drug treated mice showed lower blood sugar and far higher insulin than untreated peers. Islet and beta cell counts rose, while rival alpha cell counts fell. Tracing in special mice showed beta cells kept their identity instead of drifting. In dish tests, the drug guarded islet shape and boosted insulin release. Gains tie to self copying of beta cells and calmer immune attack.
Catalog record
| CREATOR | Wencheng Zhang, Shuo Yang, Xinwen Yu, Shanshan Zhu, Xin Wang, Fei Sun, Shengru Liang, Xiaoguang Wang, Guohong Zhao, Bin Gao, Marie Černá, Bo-Ying Bao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |