Comparative Analysis of Extracorporeal Shockwave Therapy, Bisphosphonate, and Wharton Jelly-Derived Mesenchymal Stem Cells in Preserving Bone and Cartilage Integrity and Modulating IL31, IL33, and BMP2 in the Cartilage of Ovariectomized Rat Model
Jai-Hong Cheng, Cheng-Wei Chen, Wen-Yi Chou, Po-Cheng Chen, Kuan-Ting Wu, Shun-Wun Jhan, Shan-Ling Hsu, Yi-No Wu, Hou-Tsung Chen, Elisa Belluzzi · 2024
Read Comparative Analysis of Extracorporeal Shockwave Therapy, Bisphosphonate, and Wharton Jelly-Derived Mesenchymal Stem Cells in Preserving Bone and Cartilage Integrity and Modulating IL31, IL33, and BMP2 in the Cartilage of Ovariectomized Rat Model by Jai-Hong Cheng, Cheng-Wei Chen, Wen-Yi Chou, Po-Cheng Chen, Kuan-Ting Wu, Shun-Wun Jhan, Shan-Ling Hsu, Yi-No Wu, Hou-Tsung Chen, Elisa Belluzzi (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673226.txt.
Description
Jai-Hong Cheng and co-authors race three treatments for bone loss in rats, including one that needs no drug at all. Osteoporosis thins bone and endangers cartilage, and few therapies protect both. Their 2024 paper uses rats whose ovaries were removed to mimic the disease. The rats then receive shockwave therapy on the legs, a bisphosphonate drug, or stem cells drawn from umbilical cord jelly.
All three treatments improved bone density and preserved cartilage, shifting levels of signaling proteins tied to inflammation and bone growth. The drug, zoledronic acid, produced the largest gains in bone structure and cartilage protection. Shockwave therapy, applied from outside the body, stood out as a non-invasive option with real protective effects, and the stem cells also helped measurably. The authors present the comparison as a map for clinicians weighing strength of effect against invasiveness when defending an osteoporotic joint.
Catalog record
| CREATOR | Jai-Hong Cheng, Cheng-Wei Chen, Wen-Yi Chou, Po-Cheng Chen, Kuan-Ting Wu, Shun-Wun Jhan, Shan-Ling Hsu, Yi-No Wu, Hou-Tsung Chen, Elisa Belluzzi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |