Temporal Tissue Remodeling in Volumetric Muscle Injury with Endothelial Cell-Laden Patterned Nanofibrillar Constructs
Krista M Habing, Cynthia A Alcazar, Nathaniel Dobson, Yong How Tan, Ngan F Huang, Karina H Nakayama, Filiz Ates · 2024
Read Temporal Tissue Remodeling in Volumetric Muscle Injury with Endothelial Cell-Laden Patterned Nanofibrillar Constructs by Krista M Habing, Cynthia A Alcazar, Nathaniel Dobson, Yong How Tan, Ngan F Huang, Karina H Nakayama, Filiz Ates (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673213.txt.
Description
Habing and co-authors track how engineered tissue aids shape healing after severe muscle loss, in a study from 2024. Volumetric muscle loss overwhelms the body's repair program, and blood supply often lags early on. Past work showed that patterned scaffolds can steer blood vessel cells toward healing behavior.
Mice with such an injury received scaffolds loaded with vessel cells, with the collagen fibers either aligned or random. Healing was checked at 2, 7, and 21 days. All groups gained blood vessels and new muscle at like rates. Mice with plain scaffolds lost half their muscle area over the span, while cell-loaded patterned ones kept their mass. The cell constructs also drew more fibrous remodeling near the implant.
Catalog record
| CREATOR | Krista M Habing, Cynthia A Alcazar, Nathaniel Dobson, Yong How Tan, Ngan F Huang, Karina H Nakayama, Filiz Ates |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |