Repurposed Drugs and Plant-Derived Natural Products as Potential Host-Directed Therapeutic Candidates for Tuberculosis
Rubhana Raqib, Protim Sarker · 2024
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Description
Rubhana Raqib and Protim Sarker shared a review in twenty twenty-four. It is about fighting tuberculosis by treating the patient, not the bacterium. Standard TB therapy is long and harsh. It fails against drug-resistant strains. New antibiotics take decades and fortunes to develop. Host-directed therapy boosts the body's own defenses. It sidesteps resistance in full, by design.
The review lists drugs already in use for other ends. Some are in TB trials now, as repurposed candidates. It covers plant-derived compounds in clinical or preclinical testing too. Three strategies recur through the set. They are immune modulation, autophagy enhancement, and inflammation control. Dose, timing, and patient selection get their own discussion. New drugs are slow to arrive, so old ones matter here. The authors argue the approach deserves a faster push. Its candidates are already in the pharmacy, with known safety profiles.
Catalog record
| CREATOR | Rubhana Raqib, Protim Sarker |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |