Harnessing Oxetane and Azetidine Sulfonyl Fluorides for Opportunities in Drug Discovery
Oliver · 2024
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Description
Symes and co-authors open up two small ring-shaped building blocks for drug design. Four-membered rings called oxetanes and azetidines are prized in medicine for their small, polar shape, yet they are hard to make in varied forms. The team builds versions carrying a sulfonyl fluoride group and finds that gentle heat makes them shed that group and form reactive partners.
Those partners then join with a wide range of other molecules, giving ring products that often have no close match among standard designs. The team also makes eleven versions of known drugs and hangs linker groups on the rings for attaching other cargo. They argue the reagents give drug hunters a fresh, flexible set of parts.
Catalog record
| CREATOR | Oliver |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |