Study on the Effect of Phillyrin on Streptococcus suis In Vivo and In Vitro
Fangyan Yuan, Lihan Zheng, Mengzhe Wang, Wei Liu, Xiaoyue Li, Ting Gao, Rui Guo, Zewen Liu, Keli Yang, Chang Li, Qiong Wu, Jiajia Zhu, Yongxiang Tian, Danna Zhou · 2024
Read Study on the Effect of Phillyrin on Streptococcus suis In Vivo and In Vitro by Fangyan Yuan, Lihan Zheng, Mengzhe Wang, Wei Liu, Xiaoyue Li, Ting Gao, Rui Guo, Zewen Liu, Keli Yang, Chang Li, Qiong Wu, Jiajia Zhu, Yongxiang Tian, Danna Zhou (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673059.txt.
Description
A large team in China tests a plant compound against a pig and human pathogen in a 2024 paper. The germ, Streptococcus suis type 2, causes grave disease in pigs and people and is gaining drug resistance. Phillyrin, the main active part of a classic herbal plant, is the compound under test.
In dishes, the compound broke the germ's membrane, wrecked its insides, and let DNA leak out. It also curbed the germ's grip on pig airway cells and its film growth. In animals dosed after infection, survival rose and lung swelling eased. Docking tests show the compound binds a key toxin of the germ, which may explain part of its effect.
Catalog record
| CREATOR | Fangyan Yuan, Lihan Zheng, Mengzhe Wang, Wei Liu, Xiaoyue Li, Ting Gao, Rui Guo, Zewen Liu, Keli Yang, Chang Li, Qiong Wu, Jiajia Zhu, Yongxiang Tian, Danna Zhou |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |