Protective Effect of Pentoxifylline on the Development of Acute Gastric Mucosal Injury in a Model of LPS-Induced Sepsis
Sergio D. Paredes, Jorge Hernández-Cortés, Farzin Falahat, Lisa Rancan, Javier Arias-Díaz, Elena Vara · 2024
Read Protective Effect of Pentoxifylline on the Development of Acute Gastric Mucosal Injury in a Model of LPS-Induced Sepsis by Sergio D. Paredes, Jorge Hernández-Cortés, Farzin Falahat, Lisa Rancan, Javier Arias-Díaz, Elena Vara (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673027.txt.
Description
Sergio Paredes and co-authors test in 2024 whether a drug called pentoxifylline can protect the stomach lining in rats with sepsis. Sepsis can harm the barrier that lines the stomach, in part by cutting a key fat in that lining. The drug has lowered tissue damage in other sepsis models, so the team tried early and late doses after triggering sepsis.
Sepsis lowered the protective fat and other helpful signals, while raising signs of swelling and cell damage. The authors track those changes in stomach tissue and blood, and test whether the drug softens them. Readers get a detailed lab picture of how sepsis alters the stomach and where treatment might help.
Catalog record
| CREATOR | Sergio D. Paredes, Jorge Hernández-Cortés, Farzin Falahat, Lisa Rancan, Javier Arias-Díaz, Elena Vara |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |