The Contribution of the Limbus and Collagen Fibrils to Corneal Biomechanical Properties: Estimation of the Low-Strain In Vivo Elastic Modulus and Tissue Strain
Frederick H Silver, Tanmay Deshmukh, Dominick Benedetto, Mickael Asfaw, Olivia Doyle, Nicholas Kozachuk, Kamryn Li, Elena Pierro, Giuseppe Carbone · 2024
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Description
Frederick Silver and colleagues use vibration imaging to weigh what holds the cornea's shape. Reported stiffness values for the eye's clear front window scatter absurdly, from kilopascals to gigapascals, by method. The team compares human and pig corneas with vibrational optical coherence tomography, which reads stiffness from resonant frequencies.
The limbus, the rim where cornea meets white, emerges as a stabilizer against folding and slippage. A surface layer and the front collagen fibers share a signature vibration peak. Models show strain peaking at the center, worse in the cone-shaped keratoconus cornea. Slippage starts at the rim, they argue, but cones form where stress concentrates.
Catalog record
| CREATOR | Frederick H Silver, Tanmay Deshmukh, Dominick Benedetto, Mickael Asfaw, Olivia Doyle, Nicholas Kozachuk, Kamryn Li, Elena Pierro, Giuseppe Carbone |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |