Therapeutic Potential of Dimethyl Fumarate for the Treatment of High-Fat/High-Sucrose Diet-Induced Obesity
Helber da Maia Valenca, Evelyn Caribé Mota, Andressa Caetano da Fonseca Andrade Silva, Alexsandro Tavares Figueiredo-Junior, Fernanda Verdini, Bruna Romana-Souza, Mariana Renovato-Martins, Manuella Lanzetti, Samuel dos Santos Valenca, João Alfredo Moraes, Lidija Milković · 2024
Read Therapeutic Potential of Dimethyl Fumarate for the Treatment of High-Fat/High-Sucrose Diet-Induced Obesity by Helber da Maia Valenca, Evelyn Caribé Mota, Andressa Caetano da Fonseca Andrade Silva, Alexsandro Tavares Figueiredo-Junior, Fernanda Verdini, Bruna Romana-Souza, Mariana Renovato-Martins, Manuella Lanzetti, Samuel dos Santos Valenca, João Alfredo Moraes, Lidija Milković (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11673011.txt.
Description
Helber da Maia Valenca and a large team test a licensed drug, dimethyl fumarate, against diet-driven obesity, in a study from twenty twenty-four. The drug and its active breakdown product switch on a cellular defense pathway and are already sold for skin and nerve conditions. The team asked whether they also block fat formation.
In cell cultures, the metabolite stopped precursor cells from maturing into fat cells, lowering fat-driving genes and stored fat. It also cut oxidative stress and inflammation signals. In mice fed a rich diet for sixteen weeks, four weeks of the drug trimmed calorie intake, body weight, and both deep and surface fat. Blood sugar handling improved. The authors see repurposing promise for obesity care.
Catalog record
| CREATOR | Helber da Maia Valenca, Evelyn Caribé Mota, Andressa Caetano da Fonseca Andrade Silva, Alexsandro Tavares Figueiredo-Junior, Fernanda Verdini, Bruna Romana-Souza, Mariana Renovato-Martins, Manuella Lanzetti, Samuel dos Santos Valenca, João Alfredo Moraes, Lidija Milković |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |