Precision Treatment of Metachronous Multiple Primary Malignancies Based on Constructing Patient Tumor-Derived Organoids
Yicheng Wang, Haotian Chen, Zhijin Zhang, Yanyan He, Ji Liu, Baoshuang Zhao, Qinwan Wang, Jiangmei Xu, Shiyu Mao, Wentao Zhang, Xudong Yao, Wei Li, Georgia Levidou, Pedro A José, Christos K Kontos · 2024
Read Precision Treatment of Metachronous Multiple Primary Malignancies Based on Constructing Patient Tumor-Derived Organoids by Yicheng Wang, Haotian Chen, Zhijin Zhang, Yanyan He, Ji Liu, Baoshuang Zhao, Qinwan Wang, Jiangmei Xu, Shiyu Mao, Wentao Zhang, Xudong Yao, Wei Li, Georgia Levidou, Pedro A José, Christos K Kontos (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11672942.txt.
Description
Wang and co-authors grow organoids from a patient with four primary cancers. The tumors arose over 13 years in kidney, prostate, bladder, and lung. Each was proven primary by pathology after surgery. The team grew organoids from the tumor tissue samples. Stains showed the organoids matched the parent tumors closely.
Marker patterns in organoids matched those in the patient as well. Such organoids can act as stand-ins for drug testing. Drug replies in the dish may predict replies in the patient. The team built a tailored care plan from organoid traits. The case shows a path for rare multi-cancer care.
Catalog record
| CREATOR | Yicheng Wang, Haotian Chen, Zhijin Zhang, Yanyan He, Ji Liu, Baoshuang Zhao, Qinwan Wang, Jiangmei Xu, Shiyu Mao, Wentao Zhang, Xudong Yao, Wei Li, Georgia Levidou, Pedro A José, Christos K Kontos |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |