Consequences of Early Maternal Deprivation on Neuroinflammation and Mitochondrial Dynamics in the Central Nervous System of Male and Female Rats
Diego San Felipe, Beatriz Martín-Sánchez, Khaoula Zekri-Nechar, Marta Moya, Ricardo Llorente, Jose J Zamorano-León, Eva M Marco, Meritxell López-Gallardo, Dario Siniscalco · 2024
Read Consequences of Early Maternal Deprivation on Neuroinflammation and Mitochondrial Dynamics in the Central Nervous System of Male and Female Rats by Diego San Felipe, Beatriz Martín-Sánchez, Khaoula Zekri-Nechar, Marta Moya, Ricardo Llorente, Jose J Zamorano-León, Eva M Marco, Meritxell López-Gallardo, Dario Siniscalco (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11672930.txt.
Description
Diego San Felipe and co-authors test what one day without mother does to a newborn rat's brain, in a 2024 paper. A single twenty-four-hour separation on the ninth day of life is a standard model of early stress and is known to bend later behavior. The team checked two suspects in the front brain and the memory hub: inflammation signals and the health of mitochondria, the cell's power plants.
Separated pups showed a brief rise in pro-inflammatory signals in the front region and more of a calming signal in the memory hub. Their mitochondria also thinned out, with lower density but unchanged breathing output. The authors say early stress lights region-specific inflammation in the developing brain.
Catalog record
| CREATOR | Diego San Felipe, Beatriz Martín-Sánchez, Khaoula Zekri-Nechar, Marta Moya, Ricardo Llorente, Jose J Zamorano-León, Eva M Marco, Meritxell López-Gallardo, Dario Siniscalco |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |