Mossy Fiber Sprouting in Temporal Lobe Epilepsy: The Impact of Netrin-1, DCC, and Gene Expression Changes
Melis Onay, Patrick N Harter, Katherina Weber, Albrecht Piiper, Marcus Czabanka, Karl H Plate, Thomas M Freiman, Florian Gessler, Barbara Puhahn-Schmeiser, Tanveer Singh · 2024
Read Mossy Fiber Sprouting in Temporal Lobe Epilepsy: The Impact of Netrin-1, DCC, and Gene Expression Changes by Melis Onay, Patrick N Harter, Katherina Weber, Albrecht Piiper, Marcus Czabanka, Karl H Plate, Thomas M Freiman, Florian Gessler, Barbara Puhahn-Schmeiser, Tanveer Singh (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11672915.txt.
Description
Melis Onay and co-authors study rewiring in drug-resistant epilepsy in a 2024 paper. In temporal lobe epilepsy, a scarred memory hub loses key neurons while other cells sprout new fibers, a growth called mossy fiber sprouting. Whether that sprouting drives seizures or merely follows them is debated.
The team examined nineteen hippocampus samples removed during epilepsy surgery. They mapped immune cells of the brain, guidance molecules that steer growing fibers, and gene activity. One guidance pair, a signal and its receptor, stood in focus. Linking immune states to fiber growth could reveal new ways to calm the rewiring that sustains seizures.
Catalog record
| CREATOR | Melis Onay, Patrick N Harter, Katherina Weber, Albrecht Piiper, Marcus Czabanka, Karl H Plate, Thomas M Freiman, Florian Gessler, Barbara Puhahn-Schmeiser, Tanveer Singh |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |