AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection
Tomokazu Murakawa, Jumpei Ito, Mara-Camelia Rusu, Manabu Taneike, Shigemiki Omiya, Javier Moncayo-Arlandi, Chiaki Nakanishi, Ryuta Sugihara, Hiroki Nishida, Kentaro Mine, Roland Fleck, Min Zhang, Kazuhiko Nishida, Ajay M Shah, Osamu Yamaguchi, Yasushi Sakata, Kinya Otsu · 2024
Read AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection by Tomokazu Murakawa, Jumpei Ito, Mara-Camelia Rusu, Manabu Taneike, Shigemiki Omiya, Javier Moncayo-Arlandi, Chiaki Nakanishi, Ryuta Sugihara, Hiroki Nishida, Kentaro Mine, Roland Fleck, Min Zhang, Kazuhiko Nishida, Ajay M Shah, Osamu Yamaguchi, Yasushi Sakata, Kinya Otsu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11672683.txt.
Description
Tomokazu Murakawa and co-authors studied how the heart clears out its damaged power plants, in a 2024 study. Cells recycle worn mitochondria through a process called mitophagy, and a buildup of bad mitochondria is tied to heart failure. A protein called Bcl2-L-13 drives this cleanup and also splits mitochondria into pieces small enough to remove.
Mice lacking the protein, and mice whose copy could not receive a key chemical tag, developed weak hearts under pressure strain. Their heart cells made less energy as cleanup and splitting faded. The team traced the tag to an energy-sensing enzyme called AMPK. The results show this tagged cleanup path helps the heart hold up under strain, and that its strength can be dialed by the energy sensor.
Catalog record
| CREATOR | Tomokazu Murakawa, Jumpei Ito, Mara-Camelia Rusu, Manabu Taneike, Shigemiki Omiya, Javier Moncayo-Arlandi, Chiaki Nakanishi, Ryuta Sugihara, Hiroki Nishida, Kentaro Mine, Roland Fleck, Min Zhang, Kazuhiko Nishida, Ajay M Shah, Osamu Yamaguchi, Yasushi Sakata, Kinya Otsu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |