Metatranscriptomic Analysis Reveals Actively Expressed Antimicrobial-Resistant Genes and Their Hosts in Hospital Wastewater
Yusuke Ota, Fei Chen, Isaac Prah, Samiratu Mahazu, Kimiyo Watanabe, Teruaki Kinoshita, Yoshiaki Gu, Yoko Nukui, Ryoichi Saito · 2024
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Description
Yusuke Ota and co-authors examine hospital wastewater to see which drug-resistance genes are active there, not just present. Their study appeared in 2024. Hospital drains gather resistant bacteria, yet gene surveys based on DNA alone cannot tell which genes are switched on. The team combined gene reading of both DNA and RNA from the water. They also tested the water for antibiotic traces.
They found several common antibiotics in the sample, which can push bacteria to switch resistance genes on. Genes for resistance to many drugs were the most common. Gene copies carried on plasmids, small DNA rings that jump between bacteria, showed high activity for their amount. The authors say watching active genes gives a truer picture of the risk hospital wastewater poses.
Catalog record
| CREATOR | Yusuke Ota, Fei Chen, Isaac Prah, Samiratu Mahazu, Kimiyo Watanabe, Teruaki Kinoshita, Yoshiaki Gu, Yoko Nukui, Ryoichi Saito |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |