7-O-Carboxylic Acid-Substituted 3-O-Alkyl Difluoroquercetin; An Aztreonam-Potentiating Agent Against Carbapenemase-Producing Pseudomonas aeruginosa Through Simultaneous Inhibition of Metallo-β-Lactamase and Efflux Pump
Seongyeon Lee, Taegum Lee, Mi Kyoung Kim, Joong Hoon Ahn, Seri Jeong, Ki-Ho Park, Youhoon Chong, Simone Simionatto · 2024
Read 7-O-Carboxylic Acid-Substituted 3-O-Alkyl Difluoroquercetin; An Aztreonam-Potentiating Agent Against Carbapenemase-Producing Pseudomonas aeruginosa Through Simultaneous Inhibition of Metallo-β-Lactamase and Efflux Pump by Seongyeon Lee, Taegum Lee, Mi Kyoung Kim, Joong Hoon Ahn, Seri Jeong, Ki-Ho Park, Youhoon Chong, Simone Simionatto (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11672637.txt.
Description
Seongyeon Lee and colleagues published a drug chemistry study in two thousand twenty-four on reviving an antibiotic against a stubborn germ. The germ Pseudomonas aeruginosa can destroy many antibiotics with enzymes and pump others out. The drug aztreonam fails when both defences run at once.
Earlier plant-based compounds blocked both defences but only at near-toxic doses. The team reasoned that a more water-friendly tweak would let the blocker gather where the defences sit. Their new compound blocked the enzyme and the pump together. Paired with aztreonam at modest doses, it stopped most resistant strains tested. Kill curves over time backed the pairing. The authors present it as a lead for further drug design.
Catalog record
| CREATOR | Seongyeon Lee, Taegum Lee, Mi Kyoung Kim, Joong Hoon Ahn, Seri Jeong, Ki-Ho Park, Youhoon Chong, Simone Simionatto |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |