Development of a Stringent Ex Vivo-Burned Porcine Skin Wound Model to Screen Topical Antimicrobial Agents
Ping Chen, Eliza A. Sebastian, S. L. Rajasekhar Karna, Kai P. Leung · 2024
Read Development of a Stringent Ex Vivo-Burned Porcine Skin Wound Model to Screen Topical Antimicrobial Agents by Ping Chen, Eliza A. Sebastian, S. L. Rajasekhar Karna, Kai P. Leung (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11672622.txt.
Description
Ping Chen and three co-authors build a strict ex vivo burned pig skin model to screen topical antimicrobials, in work from 2024. Rising drug resistance drives a search for new and repurposed agents for burn wounds. A controlled burn device made a set-size injury on non-sterilized pig skin, wounds were infected with target pathogens, and four known creams and agents were tested.
About one percent of skin commensals survived the burn, and they did affect screening results. Two agents cut pathogen counts by one to three logs across six pathogens. Others beat them against specific germs. Ex vivo results for two agents matched rat in vivo results closely, which supports the model's relevance for screening.
Catalog record
| CREATOR | Ping Chen, Eliza A. Sebastian, S. L. Rajasekhar Karna, Kai P. Leung |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |