Cloning and Functional Analysis of Skin Host Defense Peptides from Yakushima Tago’s Brown Frog (Rana tagoi yakushimensis) and Development of Serum Endotoxin Detection System
Taichi Aono, Saki Tamura, Yua Suzuki, Taichi Imanara, Ryosei Niwa, Yoshie Yamane, Tetsuya Kobayashi, Sakae Kikuyama, Itaru Hasunuma, Shawichi Iwamuro · 2024
Read Cloning and Functional Analysis of Skin Host Defense Peptides from Yakushima Tago’s Brown Frog (Rana tagoi yakushimensis) and Development of Serum Endotoxin Detection System by Taichi Aono, Saki Tamura, Yua Suzuki, Taichi Imanara, Ryosei Niwa, Yoshie Yamane, Tetsuya Kobayashi, Sakae Kikuyama, Itaru Hasunuma, Shawichi Iwamuro (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11672578.txt.
Description
Taichi Aono and co-authors mine the skin of a Japanese island frog for defensive peptides, and turn one assay toward detecting bacterial toxins. Frog skin is a rich source of host defense peptides, small proteins that kill microbes. Their 2024 paper clones the genes for nine such peptides from Tago's brown frog of Yakushima, spanning known families plus one new peptide they name yakushimin.
Lab-made versions of the peptides were tested against bacteria, fungi signals, and cell harm. One brevinin peptide killed Staphylococcus aureus, and two peptides visibly warped the cells of common bacteria. Several also attacked rice and plant pathogens in dose-dependent fashion. The team further built a detection system for bacterial endotoxin in serum based on peptide binding. The work joins natural-product discovery with a practical diagnostic, both drawn from one small frog's skin chemistry.
Catalog record
| CREATOR | Taichi Aono, Saki Tamura, Yua Suzuki, Taichi Imanara, Ryosei Niwa, Yoshie Yamane, Tetsuya Kobayashi, Sakae Kikuyama, Itaru Hasunuma, Shawichi Iwamuro |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |