Novel Pyrroloquinoline Quinone-Modified Cerium Oxide Nanoparticles and Their Selective Cytotoxicity Under X-Ray Irradiation
Elizaveta A Zamyatina, Olga A Goryacheva, Anton L Popov, Nelli R Popova, Anna Calarco, Raffaele Conte · 2024
Read Novel Pyrroloquinoline Quinone-Modified Cerium Oxide Nanoparticles and Their Selective Cytotoxicity Under X-Ray Irradiation by Elizaveta A Zamyatina, Olga A Goryacheva, Anton L Popov, Nelli R Popova, Anna Calarco, Raffaele Conte (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11672564.txt.
Description
Cerium oxide particles coated with a natural compound are tested as selective weapons against cancer cells under X-rays, in a 2024 study. Radiation harms healthy and cancer cells alike, so a particle that shields one kind while sensitizing the other would be valuable. The team made the coated particles and compared them with plain cerium oxide and the coating alone in mouse fibroblast and breast cancer cell lines.
The coated particles cut hydrogen peroxide levels after irradiation and hurt cancer cells at lower doses than normal cells. After a 5-gray dose, cancer cells showed bigger drops in energy markers and far more chromosome damage than fibroblasts did. The authors suggest the particles could sharpen radiotherapy.
Catalog record
| CREATOR | Elizaveta A Zamyatina, Olga A Goryacheva, Anton L Popov, Nelli R Popova, Anna Calarco, Raffaele Conte |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |