The Utility of Cyclodextrin for Countering μ-Opioid Receptor Drug Overdoses
Noriko Ogawa · 2024
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Description
Noriko Ogawa comments on a new sugar-ring molecule proposed as an antidote for fentanyl overdose. Cyclodextrins are ring-shaped sugars with greasy pockets that trap guest molecules; pharmacies have used them for decades to dissolve drugs. A study highlighted in the same journal issue engineers one ring, called SBX-Me, to trap fentanyl itself inside the body.
The idea inverts the excipient's usual job: instead of carrying a drug to its target, the ring would carry it away. Fentanyl kills more overdose victims every year, and the standard antidote has limits the commentary weighs. Ogawa sets the chemistry, the evidence, and the hurdles in context for general readers. Drug designers get a lucid tour of molecular sponge therapy.
Catalog record
| CREATOR | Noriko Ogawa |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 7 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |