Current Knowledge on CRISPR Strategies Against Antimicrobial-Resistant Bacteria
Carlos de la Fuente Tagarro, Diego Martín-González, Andrea De Lucas, Sergio Bordel, Fernando Santos-Beneit · 2024
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Description
Carlos de la Fuente Tagarro and four co-authors review how CRISPR gene editing can fight drug-resistant bacteria and find new antibiotics, in a paper from 2024. Resistance keeps outrunning drug discovery, and CRISPR can cut resistance genes directly or wake silent ones that make antibiotics. Both attack routes are surveyed.
CRISPR tools can target plasmids or chromosomes to kill or resensitize resistant cells, delivered by nanoparticles or bacteria-infecting viruses. In Streptomyces, editing has switched on silent gene clusters and revealed new compounds. Over ninety-five percent of natural products remain uncharacterized, the authors note. Uses in fungi and industrial strain improvement are also covered.
Catalog record
| CREATOR | Carlos de la Fuente Tagarro, Diego Martín-González, Andrea De Lucas, Sergio Bordel, Fernando Santos-Beneit |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |